Demonstrators gathered in groups in and around the downtown area, but were unable to converge to march towards the palace of President Omar al-Bashir. As police fired tear gas, protesters were seen taking refuge in small lanes of the capital's usually busy business district, which was deserted on Monday.
Most shops and businesses in downtown Khartoum were shut ahead of the planned march.
Monday's march was called by a group of professionals including doctors, teachers and engineers, who organised a similar rally on December 25. "We will march towards the presidential palace calling for President Omar al-Bashir to step down," the Sudanese Professionals' Association said in a statement late Sunday.