Sourcing and trading firm Li & Fung Ltd was the worst performing blue chip stock, down 4.4 percent to HK$16.20, after weak US economic data raised worries about a slowdown in the world's largest economy.
PC-maker Lenovo Group fell 4 percent to HK$3.62 ahead of first half earnings due next week. A weak second day of trade for China Construction Bank also weighed on sentiment.
Shares in CCB, China's largest overseas listing ever, ended flat at HK$2.35 with investors eyeing its high listing price amid jittery global market conditions.
The index is down 0.1 percent so far this year, outperforming Taiwan, but significantly underperforming Korean and Japanese indices.
Friday's volume was above recent averages with HK$21.9 billion (US $2.8 billion) worth of shares exchanged.
Dealers expect the Hang Seng Index to head toward the 250-day moving average near 14,170 ahead of a US rate setting meeting next Tuesday.
Dealers said a 25 basis points rate rise is widely anticipated by the market, although many expect bigger Hong Kong banks to raise prime rates by as much as 50 basis points to catch up with rate rises by their smaller rivals last time around.
Property stocks fell on continued worries that rising interest rates would dampen consumer appetite for new housing.
The Hang Seng properties sub index fell 1.3 percent. Sun Hung Kai Properties Ltd, the city's top property developer, fell 1.56 percent to HK$72.35, its lowest level in five months.
Top Asia refiner Sinopec Corp fell 3.15 percent to HK$3.075 after reporting a worse-than-expected 20.4 percent decline in third-quarter net profit as its refining losses deepened.
The world's third largest contract maker of microchips, Semiconductor Manufacturing International Corp (SMIC), tapped record lows, down 1.96 percent to HK$1.00, after posting a fourth straight quarterly loss as higher corporate expenses offset growing consumer product demand.
SMIC shares have fallen about 35 percent since the stock was listed in March 2004.
China's number 2 cellular provider China Unicom Ltd fell 0.84 percent to HK$5.90 despite reporting a better-than-expected 22.5 percent rise in third quarter profit.