He was elected President of District Local Board of Sanghar in 1954. Since then he maintained a board of winning people's endorsement in every electoral contest.
In 1962, at the age of 29 Junejo was elected a member of the West Pakistan Provincial Assembly from his home district Sanghar.
He was appointed as Minister in the West Pakistan Cabinet. He held the portfolios of Health, Basic Democracy (Local Government), Labour, Co-operatives, Works, Communications and Railways. He left his mark as a diligent man of integrity and mature judgement. All those who came into contact with him were impressed by his national outlook and abiding concern for the common man.
Junejo again participated in the elections in 1965 and emerged victorious. He was again appointed as a minister in 1965 in West Pakistan Government and remained in the provincial cabinet till March 1969. In July 1978, Junejo joined the government and as Minister for Railways and worked till April 21, 1979.
From the nation-wide elections of February 1985 he emerged a national figure enjoying support of all sections of people. In the elections to the National Assembly, Junejo was elected from his traditional constituency unopposed. On March 24 the same year he obtained a similar unanimous mandate as Prime Minister from the National Assembly.
Mohammad Khan Junejo, who was titled as "Quaid-e-Jamuhoriat" (leader of democracy) and "Koh-e-noor-e-Pakistan" has a long record of public service and a mandate from the people to act as an elected Prime Minister. After the nation-wide elections in February 1985, the President of Pakistan called upon Mohammad Khan to form the government as a civilian elected prime minister. On March 23, 1985, Junejo was sworn in as Prime Minister.
Under the rules, the Prime Minister could take another sixty days before securing a vote of confidence from the Parliament. However, he took on unique decision to appear before the elected Parliament with twenty-four hours for a vote of confidence. From the Parliament which burst into a spontaneous applause. He thus received a mandate to lead the country in the transition from martial law to a democratic civilian rule.
"The legend of the country", late Mohammad Khan Junejo a tall, noble and sober gentleman, who hailed from Sindhri, after taking oath as Prime Minister announced that "there will be no martial law" and "democracy and martial law cannot go together". Junejo also did not compromise on the "constitutional amendment package" given by late General Zia-ul-Haq and the lifting of martial law at the cost of the eight amendments is a proof of political wisdom of the late Junejo.
His another historical achievement is the Geneva accord, which is also a sign of the right political vision of late Prime Minister.
He was a "Man of Principles", who ordered an inquiry into "Ojhri Camp blast" despite of all pressures. Junejo was a straightforward person, who boldly declared on the assembly's floor that "not only the civil bureaucrats but even army generals should use the Suzuki cars".
In the first two addresses to the nation, Mohammad Khan Junejo announced not only his commitment to democratic rule but also reaffirmed his intention to further strengthen friendship with the great people of China. Junejo was a man of character and in our corrupt society the "Junejo's era" can be termed as a period when corruption was less reported. His five-point action plan was also a reflection of his political wisdom.
He gave priority to education and his programme of "Nai Roshni School" was aimed at rooting out illiteracy from the country Junejo's government was dissolved by late General Ziaul Haq on the "false charges", and in Haji Saifullah's case, the Supreme Court of Pakistan declared the declaration of dissolution of Junejo's Government and Assembly as illegal as well as unconstitutional, further Junejo was termed as "innocent" by the apex court. Late Mohammad Khan Junejo, should be remembered in our history as a "legend" and "statesman" who inspite of being a feudal from Sindh left only one widow and children of gentle and sober character.
May Almighty Allah rest the noble soul of Mohammad Khan Junejo in eternal peace in heaven(s). Ameen.